Metaplasticity


Neuronal Physiology

Posted on March 23, 2013 by Tara Thiagarajan in Science. Comments Off on Neuronal Physiology

My doctoral work was focused on understanding of the individual neuron, specifically on how it responded to changes in activity in its environment and to blocking of specific channels of input. We discovered a tuning mechanism that allowed an adjusted response depending on the level of activity and also qualitative changes in the way the neuron communicated after long periods of activity deprivation (neuron neurosis?).

I also spent many years looking for evidence of presynaptic protein translation, a finding that would suggest that synapses are more autonomous than previously thought and that neurons therefore have a much more expanded computational capability.  We found some really strong evidence but couldn’t nail it down all the way so the work remains yet unpublished….

Publications

Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons. Groth RD, Lindskog … Read More »