Dynamics of Brain Networks
My earlier academic work has focused on the dynamics of brain activity recorded using multielectrode arrays in various systems from organotypic slice cultures (2D brain networks in a dish) to electrodes implanted in awake monkeys and human patients undergoing surgical resection to treat epilepsy. The most interesting discovery was of a phenomenon called ‘Coherence Potentials’, network level waveforms with complex temporal structures that traveled through the network without distortion. Recently we were able to relate these coherence potentials to simple motor behaviors in a human patient.
Coherence potentials encode simple human sensorimotor behavior. Parameshwaran D, Crone NE, Thiagarajan TC.PLoS One. 2012;7(2):e30514.
Coherence potentials: loss-less, all-or-none network events in the cortex.Thiagarajan TC, Lebedev MA, Nicolelis MA, Plenz D. PLoS Biol. 2010 Jan12;8(1)
Comments/Blogs on this work
- Brain entanglement could explain memories (New Scientist)
- Missing Piece of Jigsaw Puzzle in Brain Message Transmission
- ‘Coherence potentials’ – the new frontier of neuronal coding? (Blog)
- Spooky action at a distance explains memory or does it (Blog)
- From Neurons to thought, coherent electrical patterns observed across the brain
Spontaneous cortical activity in awake monkeys composed of neuronal avalanches.Petermann T, Thiagarajan TC, Lebedev MA, Nicolelis MA, Chialvo DR, Plenz D. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37)
The organizing principles of neuronal avalanches: cell assemblies in the cortex? Plenz D, Thiagarajan TC. Trends Neurosci. 2007 Mar;30(3):101-10.